A new version of Django was released a couple of days ago. I'm currently at 11 sites using Django, so upgrading them all manually (which I did last time) is a pain. To help me out, I wrote a tiny Fabric script to spin through my sites, check if they're using the version of Django that was upgraded, and if they are, upgrade them.
I do a lot of development without an internet connection[1. Mostly on the train to and from work.], so being able to install packages into a virtual environment without a connection to PyPI is pretty useful.